Systematic Review and Pragmatic Clinical Approach to Oral and Nasal Vitamin B12 (Cobalamin) Treatment in Patients with Vitamin B12 Deficiency Related to Gastrointestinal Disorders
Identifieur interne : 000491 ( Main/Exploration ); précédent : 000490; suivant : 000492Systematic Review and Pragmatic Clinical Approach to Oral and Nasal Vitamin B12 (Cobalamin) Treatment in Patients with Vitamin B12 Deficiency Related to Gastrointestinal Disorders
Auteurs : Emmanuel Andrès [France] ; Abrar-Ahmad Zulfiqar ; Khalid Serraj ; Thomas Vogel ; Georges KaltenbachSource :
- Journal of Clinical Medicine [ 2077-0383 ] ; 2018.
Abstract
The objective of this review is to provide an update on the effectiveness of oral and nasal vitamin B12 (cobalamin) treatment in gastrointestinal (GI) disorders. Relevant articles were identified by PubMed and Google Scholar systematic search, from January 2010 and June 2018, and through hand search of relevant reference articles. Additional studies were obtained from references of identified studies, the Cochrane Library and the ISI Web of Knowledge. Data gleaned from reference textbooks and international meetings were also used, as was information gleaned from commercial sites on the web and data from CARE B12 research group. For oral vitamin B12 treatment, 4 randomized controlled trials (vs. intramuscular), 4 narrative and 4 systematic reviews, and 13 prospective studies fulfilled our inclusion criteria. These studies concerned patients with vitamin B12 deficiency related to: food-cobalamin malabsorption (
Url:
DOI: 10.3390/jcm7100304
PubMed: 30261596
PubMed Central: 6210286
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Systematic Review and Pragmatic Clinical Approach to Oral and Nasal Vitamin B12 (Cobalamin) Treatment in Patients with Vitamin B12 Deficiency Related to Gastrointestinal Disorders</title><author><name sortKey="Andres, Emmanuel" sort="Andres, Emmanuel" uniqKey="Andres E" first="Emmanuel" last="Andrès">Emmanuel Andrès</name><affiliation wicri:level="1"><nlm:aff id="af1-jcm-07-00304">Department of Internal Medicine, Diabetes and Metabolic Diseases, Hôpitaux Universitaires de Strasbourg, 67091 Strasbourg, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Diabetes and Metabolic Diseases, Hôpitaux Universitaires de Strasbourg, 67091 Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Zulfiqar, Abrar Ahmad" sort="Zulfiqar, Abrar Ahmad" uniqKey="Zulfiqar A" first="Abrar-Ahmad" last="Zulfiqar">Abrar-Ahmad Zulfiqar</name><affiliation><nlm:aff id="af2-jcm-07-00304">Department of Geriatrics, CHRU de Rouen, 76000 Rouen, France;<email>abzulfiqar@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Serraj, Khalid" sort="Serraj, Khalid" uniqKey="Serraj K" first="Khalid" last="Serraj">Khalid Serraj</name><affiliation><nlm:aff id="af3-jcm-07-00304">Department of Internal Medicine, CHRU, d’Oujda 60049, Morocco;<email>serrajkhalid@yahoo.fr</email></nlm:aff></affiliation></author><author><name sortKey="Vogel, Thomas" sort="Vogel, Thomas" uniqKey="Vogel T" first="Thomas" last="Vogel">Thomas Vogel</name><affiliation><nlm:aff id="af4-jcm-07-00304">Department of Geriatrics and Internal Medicine, Hôpitaux Universitaires de Strasbourg, 67091 Strasbourg, France;<email>thomas.vogel@chru-strasbourg.fr</email> (T.V.);<email>georges.kaltenbach@chru-strasbourg.fr</email> (G.K.)</nlm:aff></affiliation></author><author><name sortKey="Kaltenbach, Georges" sort="Kaltenbach, Georges" uniqKey="Kaltenbach G" first="Georges" last="Kaltenbach">Georges Kaltenbach</name><affiliation><nlm:aff id="af4-jcm-07-00304">Department of Geriatrics and Internal Medicine, Hôpitaux Universitaires de Strasbourg, 67091 Strasbourg, France;<email>thomas.vogel@chru-strasbourg.fr</email> (T.V.);<email>georges.kaltenbach@chru-strasbourg.fr</email> (G.K.)</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30261596</idno><idno type="pmc">6210286</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210286</idno><idno type="RBID">PMC:6210286</idno><idno type="doi">10.3390/jcm7100304</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000212</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000212</idno><idno type="wicri:Area/Pmc/Curation">000212</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000212</idno><idno type="wicri:Area/Pmc/Checkpoint">000142</idno><idno 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Gastrointestinal Disorders</title><author><name sortKey="Andres, Emmanuel" sort="Andres, Emmanuel" uniqKey="Andres E" first="Emmanuel" last="Andrès">Emmanuel Andrès</name><affiliation wicri:level="1"><nlm:aff id="af1-jcm-07-00304">Department of Internal Medicine, Diabetes and Metabolic Diseases, Hôpitaux Universitaires de Strasbourg, 67091 Strasbourg, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Diabetes and Metabolic Diseases, Hôpitaux Universitaires de Strasbourg, 67091 Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Zulfiqar, Abrar Ahmad" sort="Zulfiqar, Abrar Ahmad" uniqKey="Zulfiqar A" first="Abrar-Ahmad" last="Zulfiqar">Abrar-Ahmad Zulfiqar</name><affiliation><nlm:aff id="af2-jcm-07-00304">Department of Geriatrics, CHRU de Rouen, 76000 Rouen, France;<email>abzulfiqar@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Serraj, Khalid" sort="Serraj, Khalid" uniqKey="Serraj K" first="Khalid" last="Serraj">Khalid Serraj</name><affiliation><nlm:aff id="af3-jcm-07-00304">Department of Internal Medicine, CHRU, d’Oujda 60049, Morocco;<email>serrajkhalid@yahoo.fr</email></nlm:aff></affiliation></author><author><name sortKey="Vogel, Thomas" sort="Vogel, Thomas" uniqKey="Vogel T" first="Thomas" last="Vogel">Thomas Vogel</name><affiliation><nlm:aff id="af4-jcm-07-00304">Department of Geriatrics and Internal Medicine, Hôpitaux Universitaires de Strasbourg, 67091 Strasbourg, France;<email>thomas.vogel@chru-strasbourg.fr</email> (T.V.);<email>georges.kaltenbach@chru-strasbourg.fr</email> (G.K.)</nlm:aff></affiliation></author><author><name sortKey="Kaltenbach, Georges" sort="Kaltenbach, Georges" uniqKey="Kaltenbach G" first="Georges" last="Kaltenbach">Georges Kaltenbach</name><affiliation><nlm:aff id="af4-jcm-07-00304">Department of Geriatrics and Internal Medicine, Hôpitaux Universitaires de Strasbourg, 67091 Strasbourg, France;<email>thomas.vogel@chru-strasbourg.fr</email> (T.V.);<email>georges.kaltenbach@chru-strasbourg.fr</email> (G.K.)</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Clinical Medicine</title><idno type="eISSN">2077-0383</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The objective of this review is to provide an update on the effectiveness of oral and nasal vitamin B12 (cobalamin) treatment in gastrointestinal (GI) disorders. Relevant articles were identified by PubMed and Google Scholar systematic search, from January 2010 and June 2018, and through hand search of relevant reference articles. Additional studies were obtained from references of identified studies, the Cochrane Library and the ISI Web of Knowledge. Data gleaned from reference textbooks and international meetings were also used, as was information gleaned from commercial sites on the web and data from CARE B12 research group. For oral vitamin B12 treatment, 4 randomized controlled trials (vs. intramuscular), 4 narrative and 4 systematic reviews, and 13 prospective studies fulfilled our inclusion criteria. These studies concerned patients with vitamin B12 deficiency related to: food-cobalamin malabsorption (<italic>n</italic> = 6), Biermer’s disease (<italic>n</italic> = 3), veganism or vegetarianism (<italic>n</italic> = 1), total gastrectomy after Roux-en-Y gastric bypass (<italic>n</italic> = 2) and Crohn’s disease (<italic>n</italic> = 1). Four prospective studies include patients with vitamin B12 deficiency related to the aforementioned etiologies, except veganism or vegetarianism. The systematic present review documents that oral vitamin B12 replacement, at a daily dose of 1000 μg (1 mg), was adequate to normalize serum vitamin B12 levels and cure main clinical manifestations related to vitamin B12 deficiency, in GI disorders, and thus, with safety profile. For nasal vitamin B12 treatment, only one preliminary study was available. We conclude that oral vitamin B12 is an effective alternative to intramuscular vitamin B12 (except in patients presenting with severe neurological manifestations). Oral vitamin B12 treatment avoids the discomfort, contraindication (in patients with anticoagulation), and cost of monthly injections.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Jones, R H" uniqKey="Jones R">R.H. Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamada, T" uniqKey="Yamada T">T. Yamada</name></author><author><name sortKey="Alpers, D H" uniqKey="Alpers D">D.H. Alpers</name></author><author><name sortKey="Kalloo, A N" uniqKey="Kalloo A">A.N. Kalloo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Briani, C" uniqKey="Briani C">C. Briani</name></author><author><name sortKey="Dalla Torre, C" uniqKey="Dalla Torre C">C. 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Rutolo</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Kaltenbach, Georges" sort="Kaltenbach, Georges" uniqKey="Kaltenbach G" first="Georges" last="Kaltenbach">Georges Kaltenbach</name><name sortKey="Serraj, Khalid" sort="Serraj, Khalid" uniqKey="Serraj K" first="Khalid" last="Serraj">Khalid Serraj</name><name sortKey="Vogel, Thomas" sort="Vogel, Thomas" uniqKey="Vogel T" first="Thomas" last="Vogel">Thomas Vogel</name><name sortKey="Zulfiqar, Abrar Ahmad" sort="Zulfiqar, Abrar Ahmad" uniqKey="Zulfiqar A" first="Abrar-Ahmad" last="Zulfiqar">Abrar-Ahmad Zulfiqar</name></noCountry><country name="France"><noRegion><name sortKey="Andres, Emmanuel" sort="Andres, Emmanuel" uniqKey="Andres E" first="Emmanuel" last="Andrès">Emmanuel Andrès</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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